🖥️
Runs on Your Machine
Projects, conversations, experiments, logs, and artifacts stay on your computer. PG Lab AI has no server of its own and collects no usage analytics.
← Lab Tools
An AI-Powered Workspace
§ PG Lab AI · Available Now
An AI-Powered Workspace
for Scientific Discovery
Launch research agents that review literature, develop hypotheses, run experiments, and produce research artifacts - on your own machine, with your own models.
Download for macOSApple silicon & Intel · .dmgDownload for WindowsWindows 10/11 · Setup.exeDownload for Linuxx86_64 · AppImage
Free and open source. All releases · Source on GitHub
Local-firstOpen source (MIT)Clinical literatureExperiment tracking
6
Literature Sources
5
Coding Agents
8
Compute Backends
Works with the sources, agents, and compute you already use
PubMedEurope PMCClinicalTrials.govbioRxivOpenAlexalphaXivOllamaClaude CodeCodexOpenCodeSSHSlurm
§ Features
A research lab’s agent workspace
From the first literature search to the final figure, in one desktop app.
🦙
Local Models by Default
When Ollama is serving the lab's Qwen model, PG Lab AI connects it automatically and uses it for new chats - no cloud account required.
📚
Clinical Literature Search
Agents search PubMed, Europe PMC, ClinicalTrials.gov, bioRxiv, OpenAlex, and alphaXiv to ground hypotheses in published and registered evidence.
🧪
Tracked Experiments
Every experiment is a branch in a local experiment tree with its code, logs, and results recorded, so agents learn from past runs.
⚙️
Your Compute
Run on this machine, a lab GPU workstation over SSH, a Slurm cluster, Kubernetes, Ray, Modal, Hugging Face Jobs, or Tinker.
🤖
Your Choice of Agent
Works with OpenCode, Claude Code, Codex, Cursor, and Google Antigravity - switch agents per chat without changing your projects.
In Action
Agents you can watch work
Here an agent checks the lab environment - CPUs, GPUs, Python, and bioinformatics tools - before verifying a model and running smoke tests, all on a local model.
- ✓Agent runs commands and edits code in your project
- ✓Every step is visible and reviewable
- ✓Local Qwen model through Ollama
- ✓Projects and chats organized in the sidebar
§ Workflow
From question to evidence
The research loop PG Lab AI agents follow.
❓1
Ask
Describe a research question or analysis in plain language.
🔍2
Ground
The agent searches the literature and trial registries for evidence.
🧪3
Experiment
It writes code and runs experiments on your chosen compute.
📈4
Analyze
Results, logs, and figures are recorded and compared across runs.
📄5
Report
Produce figures, summaries, and LaTeX papers from the evidence.
§ FAQ
Frequently asked questions
What is PG Lab AI?+
PG Lab AI is a desktop workspace where AI research agents review literature, develop hypotheses, run experiments, and produce research artifacts. It is built by the PG Lab for pediatric surgery, genomics, and AI research.
Is PG Lab AI free and open source?+
Yes. PG Lab AI is free and open source under the MIT License. It is based on OpenResearch by alphaXiv.
Does my research data leave my computer?+
PG Lab AI itself stores everything locally and collects no analytics. Only the services you choose to use receive data: the model provider behind your coding agent, and the literature sources you search. With a local Ollama model, the agent runs entirely on your machine.
Which literature sources can agents search?+
PubMed, Europe PMC (including open full text and preprints), ClinicalTrials.gov, bioRxiv, OpenAlex, and alphaXiv. You can turn any source off in Settings.
Which local model does it use?+
If Ollama is serving qwen3.8-cc:27b-q4_K_M, PG Lab AI uses it for new chats by default. You can choose another Ollama, LM Studio, or oMLX model, or any OpenAI-compatible server.
Why does my computer warn me when I open it?+
The installers are not yet code-signed. On macOS, right-click PG Lab AI in Applications and choose Open. On Windows, choose More info, then Run anyway, on the SmartScreen prompt.
Can I use the lab's GPU workstation from my laptop?+
Yes. Add the workstation as an SSH host and select it as a compute target; experiments then run on its GPUs while you work from your laptop.
Get Started
Bring AI agents into your research
Download PG Lab AI, open a project, and ask your first research question. Free, open source, and local-first.